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BiologyCell Biology

During Which Phase of Mitosis Do Sister Chromatids Separate?

Sister chromatids separate during anaphase. Cohesin release allows them to move to opposite poles, after which each is a daughter chromosome.

Question

During which phase of mitosis do sister chromatids separate from each other?

(A) Telophase

(B) Prophase

(C) Metaphase

(D) Anaphase

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Evidence boundary

This page answers the mitosis question. Stage boundaries label a continuous process, and sister chromatid separation here is distinct from homologous chromosome separation in meiosis I. After separation, each chromatid is called a daughter chromosome.