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ChemistryOrganic Chemistry

What Type of Esters Can Undergo Claisen Reactions?

For a standard base-driven self-Claisen condensation, the ester must have at least two α-hydrogens on the reacting α-carbon. This allows enolate formation and the product deprotonation that drives the usual reaction.

Question

What type of esters can undergo Claisen condensation reactions?

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Evidence boundary

The at-least-two-α-hydrogen rule applies to the standard base-driven self-Claisen pathway. Mixed Claisen reactions distinguish donor and acceptor roles; a non-enolizable ester may be an acceptor. Specialized methods are outside this conceptual answer.